|Related Categories||Bioactive Small Molecules, Biochemicals, Cell Biology, Molecular Biology, Molecular Biology Reagents,|
|grade||for molecular biology|
|density||0.925 g/mL at 25 °C(lit.)|
|suitability||suitable for cell culture|
|foreign activity||DNase, RNase, and protease, none detected|
|storage temp.||room temp|
|Gene Information||rat ... Ppm1a(24666)|
Live Chat and Frequently Asked Questions are available for this Product.
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P280-P305 + P351 + P338-P310|
|Personal Protective Equipment||Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter|
|Hazard Codes (Europe)||C|
|Risk Statements (Europe)||34|
|Safety Statements (Europe)||26-36/37/39-45|
|RIDADR||UN 2735PSN2 8 / PGII|
|Flash Point(F)||233.6 °F|
|Flash Point(C)||112 °C|
Sambrook, J., et al. Molecular Cloning: A Laboratory Manual 2nd ed., Plainview, NY , (1989), 5.68
Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity. Li R, Kumar R, Tati S, et al. Antimicrob. Agents Chemother. 57(4), 1832-9, (2013)
Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Mandal S, Mandal A, Johansson HE, et al. Proc. Natl. Acad. Sci. U. S. A. 110(6), 2169-74, (2013)
The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator. Martín J, García-Estrada C, Kosalková K, et al. Fungal Genet. Biol. 49(12), 1004-13, (2012)
Dexamethasone decreases the spermidine and spermine concentrations and polyamine oxidase activity in rat thymus. Bjelaković G, Pavlovic D, Kocic G, et al. J. Basic Clin. Physiol. Pharmacol. 24(1), 67-72, (2013)
Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer. Silva TM, Andersson S, Sukumaran SK, et al. PLoS ONE 8(2), e55651, (2013)
Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant. Funakoshi-Tago M, Sumi K, Kasahara T, et al. PLoS ONE 8(1), e52844, (2013)
Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Kostakioti M, Hadjifrangiskou M, and Hultgren SJ Cold Spring Harb. Perspect. Med. 3(4), a010306, (2013)
Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Guo K and Li L Anal. Chem. 81(10), 3919-32, (2009)
N1N8-bis(gamma-glutamyl)spermidine cross-linking in epidermal-cell envelopes. Comparison of cross-link levels in normal and psoriatic cell envelopes. Martinet N, Beninati S, Nigra TP, et al. Biochem. J. 271(2), 305-8, (1990)
Determination of polyamines in human tissues by precolumn derivatization with 9-fluorenylmethyl chloroformate and high-performance liquid chromatography. Ekegren T and Gomes-Trolin C Anal. Biochem. 338(2), 179-85, (2005)
Determination of polyamines in human saliva by high-performance liquid chromatography with fluorescence detection. Venza M, Visalli M, Cicciu D, et al. J. Chromatogr. B. Biomed. Sci. Appl. 757(1), 111-7, (2001)
Polyamine levels in normal human skin. A comparative study of pure epidermis, pure dermis, and suction blister fluid. El Baze P, Milano G, Verrando P, et al. Arch. Dermatol. Res. 275(4), 218-21, (1983)
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Jain R, Valiante V, Remme N, et al. Mol. Microbiol. 82(1), 39-53, (2011)
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases. Philippe de Medina et al J. Med. Chem. 52, 7765-77, (2009)
Krug, M.S., Berger, S.L. Meth. Enzymol. 152, 321, (1987)
Aldrich MSDS 1, 1616:D / Corp MSDS 1 (2), 3164:C / FT-IR 2 (1), 486:C / FT-IR 1 (1), 309:D / FT-NMR 1 (1), 501:B / IR-Spectra (3), 180:F / IR-Spectra (2), 163:C / NMR-Reference 2 (1), 266:D / RegBook 1 (1), 331:G / Sax 6, 2460 / Sigma FT-IR 1 (2), 23:C / Structure Index 1, 45:C:9
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?