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S0532 Sigma

Strychnine

Synonym: (−)-Strychnine

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Description

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

Packaging

5, 10, 25, 100 g in glass bottle

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
36/37-45-60-61
RIDADR 
UN 1692 6.1/PG 1
WGK Germany 
3
RTECS 
WL2275000

Protocols & Articles

Peer-Reviewed Papers

References

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Role of inhibition in respiratory pattern generation. Janczewski WA, Tashima A, Hsu P, et al. J. Neurosci. 33(13), 5454-65, (2013)

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Synaptic ribbons influence the size and frequency of miniature-like evoked postsynaptic currents. Mehta B, Snellman J, Chen S, et al. Neuron 77(3), 516-27, (2013)

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A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. Lu Y, Dong H, Gao Y, et al. J. Clin. Invest. 123(9), 4050-62, (2013)

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Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. McCracken LM, Blednov YA, Trudell JR, et al. J. Pharmacol. Exp. Ther. 344(2), 489-500, (2013)

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The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells. Johnson SL, Kennedy HJ, Holley MC, et al. J. Neurosci. 32(31), 10479-83, (2012)

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Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. Chu Y, Fioravante D, Thanawala M, et al. J. Neurosci. 32(40), 13796-804, (2012)

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Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis. Cannon JS and Overman LE Angew. Chem. Int. Ed. Engl. 51(18), 4288-311, (2012)

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Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. Maison SF, Pyott SJ, Meredith AL, et al. J. Neurophysiol. 109(6), 1525-34, (2013)

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Sensitivity of spinal neurons to GABA and glycine during voluntary movement in behaving monkeys. Wu G and Perlmutter SI J. Neurophysiol. 109(1), 193-201, (2013)

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Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Roy NM, Arpie B, Lugo J, et al. Neurotoxicol. Teratol. 34(6), 587-91, (2012)

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Inhibitory glycine receptors: an update. Dutertre S, Becker CM, and Betz H J. Biol. Chem. 287(48), 40216-23, (2012)

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Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis. Brustein E, Côté S, Ghislain J, et al. Dev. Neurobiol. 73(2), 168-75, (2013)

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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. Born S, Levit A, Niv MY, et al. J. Neurosci. 33(1), 201-13, (2013)

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Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. Yasaka T J. Neurosci. 29(42), 13401-9, (2009)

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Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias. Fossom LH and Skolnick P J. Neural Transm. Suppl. 49, 235-44, (1997)

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[Strychnine discharge and its mechanism]. Zhan WZ, Pan LH, and Zhang JR Sheng Li Ke Xue Jin Zhan 14(1), 48-52, (1983)

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Effect of intravenously administered strychnine on the EEG recorded from the deep structure of the adult chicken telencephalon. Ookawa T and Shoumura K Poult. Sci. 52(2), 806-8, (1973)

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[Effect of strychnine and other convulsants on the processes of central inhibition (review)]. Arushanian EB Farmakol. Toksikol. 32(2), 236-44, (1969)

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The glycine receptor in the mutant mouse spastic (spa): strychnine binding characteristics and pharmacology. White, W.F. Brain Res. 329, 1, (1985)

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Resolution and chiral recognition of muscone as well as actions on neural system. Meng Y, Xiao Q, Bai JY, et al. J. Asian Nat. Prod. Res. 16(12), 1166-70, (2014)

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[Optimization and application of method to determine plasma concentration of brucine]. Wang DY, Chen J, and Cai BC Zhongguo Zhong Yao Za Zhi 38(7), 1075-8, (2013)

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[Visual cortex and its participation in retinal function regulation]. Rzaeva NM and Dmitrienko AI Vestn. Oftalmol. 129(1), 4-8, (2013)

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[Preparation and pharmacokinetics of brucine hydrogel patch]. Chen J, Li L, Qi Y, et al. Zhong Yao Cai 35(8), 1295-8, (2012)

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[Comparison on in vivo pharmacokinetics of brucine, total alkaloids of Strychni Semen and Strychni Semen pulveratum in rats]. Cai H, Wang D, Liu X, et al. Zhongguo Zhong Yao Za Zhi 37(14), 2160-3, (2012)

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Vestibular-mediated synaptic inputs and pathways to sympathetic preganglionic neurons in the neonatal mouse. Kasumacic N, Glover JC, and Perreault MC J. Physiol. 590(Pt 22), 5809-26, (2012)

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Strychnine poisoning. Smith BA J. Emerg. Med. 8(3), 321-5, (1990)

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HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. Chen X J. Neurosci. 29(3), 600-9, (2009)

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Recent studies on the synthesis of strychnine. Shibasaki M and Ohshima T Alkaloids. Chem. Biol. 64, 103-38, (2007)

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Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse. Apostolides PF and Trussell LO J. Neurosci. 33(11), 4768-81, (2013)

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Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo. Saraswati S and Agrawal SS Cancer Lett. 332(1), 83-93, (2013)

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A potentially novel nicotinic receptor in Aplysia neuroendocrine cells. White SH, Carter CJ, and Magoski NS J. Neurophysiol. 112(2), 446-62, (2014)

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Quantum chemical calculations of 1J(CC) coupling constants for the stereochemical determination of organic compounds. Bifulco G, Riccio R, Martin GE, et al. Org. Lett. 15(3), 654-7, (2013)

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Efficient measurement of the sign and the magnitude of long-range proton-carbon coupling constants from a spin-state-selective HSQMBC-COSY experiment. Saurí J and Parella T Magn. Reson. Chem. 50(11), 717-21, (2012)

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Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body. Jalabi W, Kopp-Scheinpflug C, Allen PD, et al. J. Neurosci. 33(38), 15044-9, (2013)

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Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration. Chen ZP, Liu W, Liu D, et al. J. Control. Release 162(3), 628-35, (2012)

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Experimental and theoretical investigation of 1J(CC) and (n)J(CC) coupling constants in strychnine. Williamson RT, Buevich AV, and Martin GE Org. Lett. 14(19), 5098-101, (2012)

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Strychnine--a killer from the past. Makarovsky I, Markel G, Hoffman A, et al. Isr. Med. Assoc. J. 10(2), 142-5, (2008)

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Gustatory detection of tetrodotoxin and saxitoxin, and its competitive inhibition by quinine and strychnine in freshwater fishes. Hara TJ Mar. Drugs 9(11), 2283-90, (2011)

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Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine. Chen J, Yan GJ, Hu RR, et al. Int. J. Nanomedicine 7, 3567-77, (2012)

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Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway. Shu G, Mi X, Cai J, et al. Toxicol. Lett. 222(2), 91-101, (2013)

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Effects of cathodal trans-spinal direct current stimulation on mouse spinal network and complex multijoint movements. Ahmed Z J. Neurosci. 33(37), 14949-57, (2013)

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Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. Hirata H, Ogino K, Yamada K, et al. J. Neurosci. 33(37), 14638-44, (2013)

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Using HMBC and ADEQUATE NMR data to define and differentiate long-range coupling pathways: is the Crews rule obsolete? Senior MM, Williamson RT, and Martin GE J. Nat. Prod. 76(11), 2088-93, (2013)

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Glycinergic transmission and postsynaptic activation of CaMKII are required for glycine receptor clustering in vivo. Yamanaka I, Miki M, Asakawa K, et al. Genes Cells 18(3), 211-24, (2013)

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GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. Ray TA, Heath KM, Hasan N, et al. J. Neurosci. 34(18), 6334-43, (2014)

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Fixing latent fingermarks developed by iodine fuming: a new method. Jasuja OP, Kaur A, and Kumar P Forensic Sci. Int. 223(1-3), e47-52, (2012)

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Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. Saraswati S, Alhaider AA, and Agrawal SS Chem. Biol. Interact. 206(2), 214-21, (2013)

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HMBC-1,1-ADEQUATE via generalized indirect covariance: a high sensitivity alternative to n,1-ADEQUATE. Martin GE, Williamson RT, Blinov KA, et al. Magn. Reson. Chem. 50(10), 691-5, (2012)

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Strychnine poisoning. Flood RG Pediatr. Emerg. Care 15(4), 286-7, (1999)

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Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet. Kresyun VI, Polyasny VA, Godovan VV, et al. Bull. Exp. Biol. Med. 154(4), 457-9, (2013)

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Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine. Sun JN, Chen J, and Shi YP J. Chromatogr. A 1352, 1-7, (2014)

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Merck 14,8855

Beil. 27,IV,7530

Aldrich MSDS 1, 1620:A / Corp MSDS 1 (2), 3180:C / FT-IR 2 (3), 4262:A / FT-IR 1 (2), 1066:B / FT-NMR 1 (3), 613:A / IR-Spectra (2), 1291:H / IR-Spectra (3), 1509:G / NMR-Reference 2 (2), 942:D / RegBook 1 (2), 2881:L / Sax 6, 2472 / Sigma FT-IR 1 (1), 603:C / Structure Index 1, 461:B:5

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