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S0946 Sigma

SB-668875

≥95% (HPLC), solid

  • CAS Number 274252-40-3

  • Empirical Formula (Hill Notation) C120H206N44O35S

  • Molecular Weight 2857.26

  •  PubChem Substance ID 329824188

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
InChI Key   SURUUKNICBOUOQ-JNZZMZGCSA-N
assay   ≥95% (HPLC)
form   solid
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Biochem/physiol Actions

SB-668875 is a novel, selective peptide agonist at OX2 orexin receptors. SB-668875 possesses advantages over Orexins A and B which are equipotent at OX2 orexin receptors. The orexins can cause direct and reversible depolarisation of the postsynaptic membrane. The rank order of potencies of orexin receptor agonists to excite serotonergic DRN neurones is orexin-A = orexin-B > SB-668875-DM. In contrast, the rank order of potency of these agonists to excite noradrenergic locus coreleus (LC) neurones is orexin-A > orexin-B > SB-668875-DM.

Price and Availability


Neuroscience Grant Programm
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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