• USA Home
  • S1141 - Spermine tetrahydrochloride

EMAIL THIS PAGE TO A FRIEND
S1141 Sigma

Spermine tetrahydrochloride

BioReagent, for molecular biology

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

Purchase

Properties

Related Categories DNA & RNA Purification, Molecular Biology, Plant Biotechnology, Plant Molecular Biology, Plant Nucleic Acid Purification,
Quality Level   PREMIUM
grade   for molecular biology
InChI Key   XLDKUDAXZWHPFH-UHFFFAOYSA-N
product line   BioReagent
form   solid
mp   310-311 °C (dec.)(lit.)
solubility   H2O: soluble100 mg/mL, clear, colorless to light yellow
foreign activity   DNase, RNase, protease, NICKase, none detected
storage temp.   room temp

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Price and Availability


Microcon Centrifugal Filters

Discover the Milli-Q® IQ 7000 ultrapure water system
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EJ7230000
Protocols & Articles

Articles

Spermine tetrahydrochloride for molecular biology

CAS RN 306-67-2 EC 206-189-8 Synonyms: N, N’-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Keywords: Biochemistry, Buffers, Building blocks, Crystallization, Mass spectrometry, Melting, Molecular biology, Precipitation

Related Content

Flow Cytometry Protocol

By focusing on analysis techniques and protocols specific for Cancer Research, Sigma-Aldrich is putting your research needs first. We will be featuring different cancer research tools throughout the ...
Keywords: Buffers, Cancer, Cell culture, Culture media, Degradations, Detergents, Digestions, Flow cytometry

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

related product

Product #

Description

Add to Cart

S0266 Spermidine, BioReagent, for molecular biology, suitable for cell culture, ≥98%

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?