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  • S1190 - Anti-SLIPR/MAGI-3 antibody produced in rabbit

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S1190 Sigma

Anti-SLIPR/MAGI-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
species reactivity   rat
application(s)   indirect immunofluorescence: 2.0 μg/mL using 293T cells transfected with recombinant Slipr.
  microarray: suitable
  western blot (chemiluminescent): 1.0 μg/mL using extracts of 293T cells transfected with recombinant Slipr
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 140-160 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Magi3(245903)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.

General description

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.2

MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,6 and Receptor Tyrosine Phosphatase β (RPTPβ).7

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.

Specificity

Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.

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