|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors,|
|solubility||DMSO: soluble19 mg/mL|
Protein tyrosine kinase inhibitor (IC50 = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.
Light sensitive and packaged under nitrogen.
Certificate of Analysis
Certificate of Origin
Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo. Yamawaki T, Shimokawa H, Kozai T, et al. J. Am. Coll. Cardiol. 32(3), 780-6, (1998)
Hydrogen peroxide-induced phospholipase D activation in rat pheochromocytoma PC12 cells: possible involvement of Ca2+-dependent protein tyrosine kinase. Ito Y, Nakashima S, and Nozawa Y J. Neurochem. 69(2), 729-36, (1997)
Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo. Kozai T, Shimokawa H, Fukumoto Y, et al. J. Cardiovasc. Pharmacol. 29(4), 536-45, (1997)
Suppression of metastatic potential of high-metastatic Lewis lung carcinoma cells by vanadate, an inhibitor of tyrosine phosphatase, through inhibiting cell-substrate adhesion. Takenaga K Invasion Metastasis 16(2), 97-106, (1996)
Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors. Burke-Gaffney A and Hellewell PG Br. J. Pharmacol. 119(6), 1149-58, (1996)
Investigation of the role of protein kinase C and tyrosine kinases during the rapid and sustained release of superoxide from adherent human neutrophils. Lindsay MA, Daniels I, and Fletcher J Biochem. Soc. Trans. 24(1), 67S, (1996)
Activation of the macrophage respiratory burst by phorbol myristate acetate: evidence for both tyrosine-kinase-dependent and -independent pathways. Green SP and Phillips WA Biochim. Biophys. Acta 1222(2), 241-8, (1994)
Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase. Hirst SJ, Webb BL, Giembycz MA, et al. Am. J. Respir. Cell. Mol. Biol. 12(2), 149-61, (1995)
Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo. Ito A, Shimokawa H, Kadokami T, et al. J. Clin. Invest. 96(3), 1288-94, (1995)
The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells. Miyamoto H, Matsui K, and Arai T Int. J. Immunopharmacol. 17(5), 433-41, (1995)
Effects of herbimycin A and ST638 on Fc epsilon receptor-mediated histamine release and Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells. Teshima R, Ikebuchi H, Sawada J, et al. Biochim. Biophys. Acta 1221(1), 37-46, (1994)
Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes. Vocks A, Petković M, and Arnhold J Cell Physiol. Biochem. 13(3), 165-72, (2003)
Tyrosine and calcium/calmodulin kinases are common signaling components in the generation of reactive oxygen species in human lymphocytes. Orie NN, Zidek W, and Tepel M Life Sci. 65(20), 2135-42, (1999)
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