|Related Categories||Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S,|
|potency||≥720 I.U. per mg|
|suitability||suitable for mouse embryo cell culture|
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Recommended for use in embryo culture at 50 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at -20 °C for extended periods. Solutions are stable at 37 °C for 3 days. Use to inhibit bacterial protein synthesis at the level of initiation. Use to study mechanisms of streptomycin resistance. Use together with penicillin and other agents to inhibit bacterial contamination in cell culture applications.
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|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||63-22|
|Safety Statements (Europe)||36/37|
Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere wi...
BioFiles 2006, 1.4, 17.
Keywords: Antibiotics, Environmental, Peptide synthesis
Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease. Sarfo FS, Converse PJ, Almeida DV, et al. PLoS Negl. Trop. Dis. 7(3), e2101, (2013)
Molecularly imprinted polymers on the surface of silica microspheres via sol-gel method for the selective extraction of streptomycin in aqueous samples. Junjie L, Mei Y, Danqun H, et al. J. Sep. Sci. 36(6), 1142-8, (2013)
Isoniazid- and streptomycin-resistant miliary tuberculosis complicated by intracranial tuberculoma in a Japanese infant. Ishiwada N, Tokunaga O, Nagasawa K, et al. Tohoku J. Exp. Med. 229(3), 221-5, (2013)
Bactericidal activity does not predict sterilizing activity: the case of rifapentine in the murine model of Mycobacterium ulcerans disease. Almeida DV, Converse PJ, Li SY, et al. PLoS Negl. Trop. Dis. 7(2), e2085, (2013)
Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine. Maltby R, Leatham-Jensen MP, Gibson T, et al. PLoS ONE 8(1), e53957, (2013)
Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Derewacz DK, Goodwin CR, McNees CR, et al. Proc. Natl. Acad. Sci. U. S. A. 110(6), 2336-41, (2013)
Wolbachia from the planthopper Laodelphax striatellus establishes a robust, persistent, streptomycin-resistant infection in clonal mosquito cells. Fallon AM, Baldridge GD, Higgins LA, et al. In Vitro Cell. Dev. Biol. Anim. 49(1), 66-73, (2013)
Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of labisia pumila benth: from microwave obtained extracts. Karimi E, Jaafar HZ, and Ahmad S BMC Complement Altern. Med. 13, 20, (2013)
Interleukin 6 augments mechanical strain-induced C-reactive protein synthesis via the stretch-activated channel-nuclear factor κ B signal pathway. Zhou H, Li Y, Huang G, et al. Heart 99(8), 570-6, (2013)
The revaluation of a single low dose of streptomycin powder in chemical labyrinthectomy for Ménière's disease: our experience in ninety-eight patients. Kim SH, Choi HS, Koh SH, et al. Clin. Otolaryngol. 37(6), 491-6, (2012)
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