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S1563 Sigma

SKF-86466 hydrochloride

solid, ≥98% (HPLC)

Synonym: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists, Biochemicals and Reagents, Cell Biology,
InChI Key   JKQKVNMNAIFCFS-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   white
solubility   H2O: soluble24 mg/mL
Gene Information   human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.

Biochem/physiol Actions

SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans. The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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