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N-Allyl-(±)-SKF-38393 hydrobromide

solid, ≥98% (HPLC)

Synonym: (±)-SKF-77434 hydrobromide, (±)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

  • CAS Number 300561-58-4

  • Empirical Formula (Hill Notation) C19H21NO2 · HBr

  • Molecular Weight 376.29

  •  MDL number MFCD00243077

  •  PubChem Substance ID 24277936

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Properties

Related Categories A-AM, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
InChI Key   JWQRAXTWDYUBFI-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   white to off-white
solubility   ethanol: soluble3.2 mg/mL
  DMSO: >50 mg/mL
  H2O: soluble6.0 mg/mL
  0.1 M HCl: soluble6.3 mg/mL
storage temp.   2-8°C
Gene Information   human ... DRD1(1812)

Description

Caution

Light sensitive

Application

N-Allyl-(±)-SKF-38393 hydrobromide was used to study dopaminergic signaling in neurons of developing mice and cardiomyocytes injured by oxidants.

Biochem/physiol Actions

N-Allyl-(±)-SKF-38393 hydrobromide is a selective agonist of D1/D5 dopamine receptors. It mimics the physiological action of dopamine and enhances cognition, memory and learning. It decreases the age-related decline in long-term potentiation of mouse hippocampus. SKF-38393 increases the D1-mediated locomotion in rats.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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