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  • S192 - Anti-SDF-1/PBSF antibody produced in goat

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S192 Sigma

Anti-SDF-1/PBSF antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor

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Description

Immunogen

recombinant human SDF-1/PBSF expressed in E. coli.

General description

Stromal cell-derived factor-1 (SDF-1) is a proinflammatory cytokine that belongs to the CXC family of chemokines. The effects of SDF-1 are mediated by its binding to the receptor CXCR4, and sometimes to CXCR7. Both lymphoid (bone marrow, spleen and thymus) and non-lymphoid (stomach, kidney, liver, lung, brain, heart) organs express SDF-1. The most important functions assigned to SDF-1 are angiogenesis, migration of μglia and astrocytes, tissue repair and as chemoattractant to hematopoietic cells. Studies also implicate SDF-1 in survival of human glioma cells via the activation of PI3K/Akt pathway. The other pathways that are activated by SDF-1 include MAPK, NF-κB, paxillin, Crk and other focal adhesion proteins. A variety of human malignancies of pancreas, breast, prostate and glioma exhibit overexpression of CXCR4. High expression of SDF-1 has been observed in lymph nodes, lungs, bone and liver that are the most common sites of metastasis of breast cancer cells
This antibody can be used for the localization and detection of human SDF-1/PBSF. It can detect human SDF-1α and SDF-1β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose..

Specificity

The antibody may be used for neutralization of SDF-1α and SDF-1β, and for localization and detection of human SDF-1/PBSF.

Application

Anti-SDF-1/PBSF antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA, the recommended working antibody concentration is 0.5-1.0 μg/ml. The antibody is also suitable for neutralization assays.

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Safety & Documentation

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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