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S2066 Sigma

Signal Transduction

  •  ISBN-10 0-12-289631-9

  •  ISBN-13 978-0-12-289631-6

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publication info   B.D. Gomperts, et al., Academic Press, 2002, 424 pp., hard cover
mfr. no.   Elsevier

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General description

This text explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and coordinated. The first half explains the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. Later it deals with the formation of complex signaling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, to regulate gene transcription. It ends with a description at the molecular level of how signaling proteins interact with their environment and with each other through their structural domains.

Table of Contents

Prologue: Signal transduction, origins and personalities.
First messengers.
Receptors.
GTP-binding proteins and signal transduction.
Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase.
The regulation of visual transduction.
Calcium and signal transduction.
Calcium signaling.
Phosphorylation and dephosphorylation:protein kinases A and C.
Growth Factors :setting the framework.
Signaling pathways operated by receptor protein tyrosine kinases.
Signaling pathways operated by non-receptor protein tyrosine kinases.
Phosphoinositide 3-kinases.
Signal transduction to and from adhesion molecules.
Adhesion molecules and trafficking of leukocytes.
Signaling through receptor bound protein serine-threonine kinases.
Protein dephosphorylation and protein phosphorylation.
Protein domains and signal transduction.

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