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S2188 Sigma

γ-Secretase inhibitor

≥90% (TLC), powder

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Description

Application

γ-Secretase inhibitor was used to inhibit proteolytic processing of the transmembrane receptor, p75NTR in CNS myelin extract from rats and megalin COOH-terminal fragment in opossum kidney proximal tubule cells.

Biochem/physiol Actions

γ-Secretase activity is essential for the cleavage of β-amyloid precursor protein and the generation of amyloid β-peptide. γ-Secretase inhibitor are effective in preventing the accumulation of amyloid β-peptide in Alzheimer′s disease patients. It also inhibits the proteolytic processing of Notch protein and may be effective in treatment of colorectal neoplastic disease.

Price and Availability


Making Headway

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Non-Small Cell Lung Cancer (NSCLC)

Non-small cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. It is a disease in which mal...
Keywords: Antitumor agents, Apoptosis, Cancer, Clinical, Diagnostic, Diseases, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Ligands, Oncology, Thin layer chromatography

The Cancer Stem Cell Hypothesis

Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
Keywords: Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Cell signaling, Clinical, Degradations, Environmental, Gastrointestinal, Gene expression, Ligands, Phosphorylations, Poisons, Transcription, Transfection, transformation

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癌症干细胞

传统观点认为,癌症是环境或内部因素诱导正常细胞内的关键致癌基因和肿瘤抑制基因突变导致的一种疾病。当这些突变导致细胞向更原始、高度增殖状态转化,克隆扩张形成白血病或实体肿瘤时,就会出现癌症的临床表现1。然而,这种模式不能够完全解释许多肿瘤和转移瘤的长发育延迟,产生细胞去分化和细胞永生的起始诱导机制,或肿瘤本身内的细胞功能和表型多样性起源。过去十年中,越来越多的证据表明,恶性肿瘤起源于组织干细胞在突...
Keywords: Angiogenesis, Cancer, Eliminations, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations

Peer-Reviewed Papers
15

References

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