γ-Secretase inhibitor ≥90% (TLC), powder

Properties

Related Categories	γSecretase, Aldehydes, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C13-C60, Carbonyl Compounds, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Neurodegenerative Disease Peptides, Neuropeptides, Organic Building Blocks, Other Alzheimer’s Peptides, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, R to Z, S, gamma Secretase More...
assay	≥90% (TLC)
form	powder
solubility	DMSO: soluble
shipped in	dry ice
storage temp.	−20°C

Description

Biochem/physiol Actions

A reversible γ-secretase inhibitor.

Price and Availability

Related Papers

Peptidomimetic probes and molecular modeling suggest that Alzheimer’s γ-secretase is an intramembrane-cleaving aspartyl protease. Wolfe, M.S., et al. Biochemistry 38, 4720, (1999)

Documents

Certificate of Analysis

Certificate of Origin

S2188 - Datasheet (24 KB)

S2188 - Product Information Sheet (27 KB)

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

The Cancer Stem Cell Hypothesis

Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
Vicki Caligur
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation