|Related Categories||γSecretase, Aldehydes, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks,|
|shipped in||dry ice|
γ-Secretase inhibitor was used to inhibit proteolytic processing of the transmembrane receptor, p75NTR in CNS myelin extract from rats7 and megalin COOH-terminal fragment in opossum kidney proximal tubule cells.8
γ-Secretase activity is essential for the cleavage of β-amyloid precursor protein and the generation of amyloid b-peptide. γ-Secretase inhibitor are effective in preventing the accumulation of amyloid β-peptide in Alzheimer′s disease patients.4 It also inhibits the proteolytic processing of Notch protein and may be effective in treatment of colorectal neoplastic disease.5
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Traditionally, cancer has been viewed as a disease in which environmental or endogenous events induce mutations to critical oncogenes and tumor suppressor genes within a normal cell. The clinical man...
BioFiles 2008, 3.5, 4.
Keywords: Angiogenesis, Apoptosis, Asymmetric synthesis, Cancer, Catalysis, Cell culture, Cell division, Cell proliferation, Clinical, DNA replication, Degradations, Eliminations, Environmental, Gastrointestinal, Gene expression, Growth factors, Ligands, Metabolic Pathways, Phosphorylations, Poisons, Transcription, Transfection, transformation
Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro. Ahmed Z, Suggate EL, Brown ER, et al. Brain 129(Pt 6), 1517-33, (2006)
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