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  • S2562 - Anti-Stem Cell Factor Receptor (SCF R) antibody produced in goat

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S2562 Sigma

Anti-Stem Cell Factor Receptor (SCF R) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CD117

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Description

Immunogen

recombinant human stem cell factor receptor (SCF R) extracellular domain expressed in Sf 21 cells.

General description

Mast cells play an important role in innate immunity or the response of the body to invading pathogens. The functions of mast cells are regulated by a number of surface receptors; Stem cell factor receptor (SCF R; CD117) being the most critical. The signalling triggered by SCF R results in mast cell activation in response to antigens. The response involves tyrosine phosphorylation by specific tyrosine kinases that drive the downstream signalling process. The secondary pathways activated by SCF R include Akt, mTOR, MAPK and c-Jun. In addition to development of mast cells, SCF R also regulates their subsequent maturation and homing to the residence sites. Constitutive activation by SCF R is implicated in myeloproliferative discorders, systemic mastocytosis and gastrointestinal stomal cell tumors
Anti-human stem cell factor receptor recognizes recombinant human SCF receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Application

Anti- stem cell factor receptor antibody may be used to neutralize human SCF R at neutralization dose (ND50) of 0.3-1.0 μg/ml. For ELISA, the recommended antibody concentration is 0.5-1.0 μg/ml. The antibody is suitable for immunoblotting at a working concentration of 0.1-0.2 μg/ml.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  1
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