|Related Categories||Aminoglycosides, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,|
|grade||for molecular biology|
|suitability||nonselective for Escherichia coli and Coliforms|
Mode of Action: Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (Gonnococcus only).
Mode of Resistance: Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
Spectinomycin is an antimicrobial agent effective against Gram-negative and Gram-positive bacteria. It is used as a selective agent for bacteria with spectinomycin resistance.
Spectinomycin binds to the 30S ribosomal subunit and inhibits protein synthesis, leading to cell death.
Prepare stock solution directly in the vial with sterile water to a final concentration of 10mg/mL. Stock solution should be stored at 2-8 or -20°C.
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Ready Made Solution, 100 mg/mL in DMSO/H2O, 1:1, 0.2 μm filtered
potency: ≥603 μg per mg
powder, BioReagent, suitable for cell culture
VETRANAL™, analytical standard
Multiplex bead suspension array for screening Neisseria gonorrhoeae antibiotic resistance genetic determinants in noncultured clinical samples. Balashov S, Mordechai E, Adelson ME, et al. J. Mol. Diagn. 15(1), 116-29, (2013)
Physiologic consequences of glucose transport and phosphoenolpyruvate node modifications in Bacillus subtilis 168. Cabrera-Valladares N, Martínez LM, Flores N, et al. J. Mol. Microbiol. Biotechnol. 22(3), 177-97, (2012)
[Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility]. Zhou Y, Xu XL, Wang CP, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 25(3), 201-4, (2011)
In vitro antimicrobial inhibition of Mycoplasma bovis isolates submitted to the Pennsylvania Animal Diagnostic Laboratory using flow cytometry and a broth microdilution method. Soehnlen MK, Kunze ME, Karunathilake KE, et al. J. Vet. Diagn. Invest. 23(3), 547-51, (2011)
Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations. Vučićević-Prčetić K, Cservenák R, and Radulović N J. Pharm. Biomed. Anal. 56(4), 736-42, (2011)
2-Oxoglycosyl ("ulosyl") and 2-oximinoglycosyl bromides: versatile donors for the expedient assembly of oligosaccharides with β-D-mannose, β-L-rhamnose, N-acetyl-β-D-mannosamine, and N-acetyl-β-D-mannosaminuronic acid units. Lichtenthaler FW Chem. Rev. 111(9), 5569-609, (2011)
The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation. Cahoon LA, Stohl EA, and Seifert HS Mol. Microbiol. 79(3), 729-42, (2011)
Simultaneous determination of lincomycin and spectinomycin residues in animal tissues by gas chromatography-nitrogen phosphorus detection and gas chromatography-mass spectrometry with accelerated solvent extraction. Tao Y, Chen D, Yu G, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(2), 145-54, (2011)
Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway. Unemo M, Golparian D, Skogen V, et al. Antimicrob. Agents Chemother. 57(2), 1057-61, (2013)
Visual spectinomycin resistance (aadA(au)) gene for facile identification of transplastomic sectors in tobacco leaves. Tungsuchat-Huang T, Slivinski KM, Sinagawa-Garcia SR, et al. Plant Mol. Biol. 76(3-5), 453-61, (2011)
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