Sulindac sulfide
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
(Z)
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CAS Number 32004-67-4
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Empirical Formula (Hill Notation) C20H17FO2S
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Molecular Weight 340.41
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EC Number 250-892-2
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MDL number MFCD00869764
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PubChem Substance ID 24899543
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Popular Documents: Datasheet (PDF)
Properties
| Related Categories | A to C, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, |
| assay | ≥98% (HPLC) |
| form | solid |
| color | yellow |
| solubility | DMSO: ≥22 mg/mL |
Description
Biochem/physiol Actions
Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism.
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