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S3313 Sigma

SB-204070 hydrochloride

solid, ≥97% (HPLC)

Synonym: (1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride

  • CAS Number 148702-58-3

  • Empirical Formula (Hill Notation) C19H27ClN2O4 · HCl

  • Molecular Weight 419.34

  •  MDL number MFCD03453014

  •  PubChem Substance ID 24278704

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Description

Biochem/physiol Actions

Selective 5-HT4 serotonin receptor antagonist.

SB-204070 is a highly potent and specific antagonist of 4-HT4 receptor. It inhibits cholinergic and noncholinergic transmission and blocks the contractions of proximal colon in guinea pigs and relaxation of human colon circular smooth muscle.

Legal Information

Manufactured and sold under exclusive license from GlaxoSmithKline Pharmaceuticals

Application

SB-204070 hydrochloride was used to study the role of 5-HT metabolites in trypsin-induced anion secretion in mouse cecum.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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