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S3523 Sigma

Surfactin

from Bacillus subtilis, ≥98% (HPLC and TLC)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,
biological source   from Bacillus subtilis
description   zwitterionic
InChI Key   NJGWOFRZMQRKHT-WGVNQGGSSA-N
assay   ≥98% (HPLC and TLC)
form   powder
CMC   7.5-20 μmol/L (depending on methods)
solubility   ethanol: soluble10 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  fungi
  mycoplasma
  neoplastics
  viruses
storage temp.   2-8°C

Description

Packaging

10, 50 mg in poly bottle

Application

Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. It is also used to study antitumor activity, activity against enveloped viruses, activity against the protoplast of Bacillus megaterium and the activity against Mycoplasma.

Biochem/physiol Actions

Surfactin is a lipopeptide antibiotic that is composed of one β-hydroxy fatty acid, which has a long fatty acid moiety, and seven amino acids. Three of them have D configurations. It is a powerful biosurfactant that causes lysis of erythrocytes and bacteria. It is also a clotting inhibitor. Surfactin is thought to disrupt or disintegrate membranes via physicochemical interaction with the membranes.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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