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S3572 Sigma

Stevioside hydrate

≥98% (HPLC)

Synonym: (4α-13-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]kaur-16-en-18-oic acid β-D-glucopyranosyl ester

  • CAS Number 57817-89-7 (anhydrous)

  • Empirical Formula (Hill Notation) C38H60O18 · xH2O

  • Molecular Weight 804.87 (anhydrous basis)

  •  PubChem Substance ID 329824534

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
biological source   from Stevia sp.
InChI Key   FVECWZKNZGXJJO-QMYNVHDOSA-N
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: 25 mg/mL clear
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Preparation Note

Stevioside solutions should be prepared in DMSO. Highly pure stevioside has very poor water solubility.

Application

Stevioside-induced ROS-mediated apoptosis was studied in human breast cancer cells.

Biochem/physiol Actions

Stevioside is a noncaloric natural sweetener, 300 times more potent than sucrose. It inhibits transepithelial transport of p-aminohippurate (PAH) by interfering with the organic anion transport system. At 0.5-1 mM, it showed no interaction with any organic anion transporters (OAT).

Stevioside reportedly has genotoxic effects in cultured mammalian cells.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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