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S3939 Sigma

Staurosporine aglycone

≥95%

Synonym: K-252c

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Description

Biochem/physiol Actions

K-252c is a PKC inhibitor active at submicromolar concentrations.

Staurosporine is a microbial alkaloid that inhibits protein kinase C (PKC) but lacks selectivity and may inhibit other protein kinases. Substitution of one of the indole nitrogen atoms by non-glycosidic indolocarbazoles lacking aminoalkyl side chain results in Staurosporine aglycone with increased selectivity for PKC. Staurosporine aglycone inhibits the autophosphorylation of c-Met and activation of MAPK and Akt in cancer cells.

Packaging

1, 5 mg in glass bottle

Application

RGC-5 cells were treated with Staurosporine aglycone to study the effect of staurosporine analogs on the process of neuronal differentiation.

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Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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S3939 Staurosporine aglycone, ≥95%

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