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S3939 Sigma

Staurosporine aglycone

≥95%

Synonym: K-252c

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Description

Biochem/physiol Actions

K-252c is a PKC inhibitor active at submicromolar concentrations.

Staurosporine is a microbial alkaloid that inhibits protein kinase C (PKC) but lacks selectivity and may inhibit other protein kinases. Substitution of one of the indole nitrogen atoms by non-glycosidic indolocarbazoles lacking aminoalkyl side chain results in Staurosporine aglycone with increased selectivity for PKC. Staurosporine aglycone inhibits the autophosphorylation of c-Met and activation of MAPK and Akt in cancer cells.

Packaging

1, 5 mg in glass bottle

Application

RGC-5 cells were treated with Staurosporine aglycone to study the effect of staurosporine analogs on the process of neuronal differentiation.

Price and Availability


DISCOVER Bioactive Small Molecules

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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S3939 Staurosporine aglycone, ≥95%

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