|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase Kinase (MAPKK),|
|protect from light|
|color||white to off-white|
|solubility||DMSO: >10 mg/mL|
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats.1 It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.2
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors Fernandez SM et al J. Neurosci. 28, 8660-7, (2008)
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