S4069 Sigma


≥98% (HPLC), Mixture of E & Z isomers, solid

Synonym: α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327

  • CAS Number 305350-87-2

  • Empirical Formula (Hill Notation) C16H12F3N3S

  • Molecular Weight 335.35

  •  MDL number MFCD06411432


Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase Kinase (MAPKK),
assay   ≥98% (HPLC)
form   solid
storage condition   desiccated
  protect from light
color   white to off-white
mp   127-128.2 °C
solubility   DMSO: >10 mg/mL
  H2O: insoluble
storage temp.   2-8°C



SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats.1 It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.2

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

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