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S4139 Sigma

Spermidine

suitable for cell culture, BioReagent

Synonym: 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
InChI Key   ATHGHQPFGPMSJY-UHFFFAOYSA-N
product line   BioReagent
assay   ≥98% (GC)
form   liquid (clear, colorless to light yellow or white)
  solid (white)
refractive index   n20/D 1.479(lit.)
density   0.925 g/mL at 25 °C(lit.)
suitability   suitable for cell culture
storage temp.   2-8°C
Gene Information   rat ... Ppm1a(24666)

Description

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2735PSN2 8 / PGII
WGK Germany 
3
RTECS 
EJ7000000
Flash Point(F) 
233.6 °F
Flash Point(C) 
112 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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S4264 Spermine, amorphous semi-solid, BioReagent, suitable for cell culture
P5780 Putrescine dihydrochloride, powder, BioReagent, suitable for cell culture

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