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S4451 Sigma

Sal003

≥98% (HPLC)

Synonym: (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression,
InChI Key   TVNBASWNLOIQML-IZZDOVSWSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
  protect from light
color   white
solubility   DMSO: ≥10 mg/mL
compatibility   for use with Bio-Rad CFX96
storage temp.   2-8°C

Description

Biochem/physiol Actions

Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.

Packaging

5, 25 mg in glass bottle

Application

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

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Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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