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S4525 Sigma

Superoxide Dismutase from Bacillus stearothermophilus

lyophilized powder, ≥2,000 units/mg protein

Synonym: SOD, Superoxide: superoxide oxidoreductase

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Properties

form   lyophilized powder
composition   Protein, ~70% biuret
storage temp.   2-8°C

Description

Analysis Note

For assay method, see McCord, J.M. and Fridovich, I., J. Biol. Chem., 244, 6049 (1969).

Biochem/physiol Actions

Catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby promoting the activity of NO.1 SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines and transgenic mice.2,3

Unit Definition

One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.

Physical form

Lyophilized powder containing potassium phosphate buffer salts

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Safety & Documentation

Safety Information

WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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S5389 Superoxide Dismutase from Escherichia coli, lyophilized powder, ≥1,000 units/mg protein

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