EMAIL THIS PAGE TO A FRIEND

S5261 Sigma

Sodium selenite

BioReagent, suitable for cell culture, ≥98%

Purchase

Properties

Related Categories Antioxidant, Cell Biology, Chemical Synthesis, Functional Foods, Inorganic Salts,
product line   BioReagent
assay   ≥98%
form   powder
mp   >350 °C(lit.)
suitability   suitable for cell culture

Description

Application

Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.

This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.

Price and Availability

Customers Also Viewed

Progesterone

powder, BioReagent, suitable for cell culture

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

Sodium selenite

γ-irradiated, lyophilized powder, BioXtra, suitable for cell culture

Sodium selenite

anhydrous, ≥95.0% (RT)

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
Contact with acids liberates toxic gas.
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
28-36/37-45-61
RIDADR 
UN 2630PSN2 6.1 / PGI
WGK Germany 
2

Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Lessons from basic research in selenium and cancer prevention. Ip, C. J. Nutr. 128, 1845-1854, (1998)

Loading...


Microbiological selenate to selenite conversion for selenium removal. Hageman SP, van der Weijden RD, Weijma J, et al. Water Res. 47(7), 2118-28, (2013)

Loading...


[Selenium and oxidative stress in cancer patients]. Gorozhanskaia ÉG, Sviridova SP, Dobrovol'skaia MM, et al. Biomed. Khim. 59(5), 550-62, (2013)

Loading...


Optimization of selenylation conditions for Chinese angelica polysaccharide based on immune-enhancing activity. Qin T, Chen J, Wang D, et al. Carbohydr. Polym. 92(1), 645-50, (2013)

Loading...


Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure. Pacitti D, Wang T, Page MM, et al. Aquat. Toxicol. 130-131, 97-111, (2013)

Loading...


Colostrum and milk selenium, antioxidative capacity and immune status of dairy cows fed sodium selenite or selenium yeast. Salman S, Dinse D, Khol-Parisini A, et al. Arch. Anim. Nutr. 67(1), 48-61, (2013)

Loading...


Oxidation inhibits iron-induced blood coagulation. Pretorius E, Bester J, Vermeulen N, et al. Curr. Drug Targets 14(1), 13-9, (2013)

Loading...


Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E. Kalender S, Uzun FG, Demir F, et al. Food Chem. Toxicol. 55, 456-62, (2013)

Loading...


Protective effects of vitamin E and selenium against dimethoate-induced cardiotoxicity in vivo: biochemical and histological studies. Amara IB, Soudani N, Hakim A, et al. Environ. Toxicol. 28(11), 630-43, (2013)

Loading...


Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials. Jirong Y, Huiyun P, Zhongzhe Y, et al. Osteoarthr. Cartil. 20(7), 605-13, (2012)

Loading...


Effects of dietary selenium supplementation on tissue selenium distribution and glutathione peroxidase activity in Chinese Ring necked Pheasants. Juniper DT and Bertin G Animal 7(4), 562-70, (2013)

Loading...


Application of reversed-phase high-performance liquid chromatography with fluorimetric detection for simultaneous assessment of global DNA and total RNA methylation in Lepidium sativum: effect of plant exposure to Cd(II) and Se(IV). Yanez Barrientos E, Wrobel K, Lopez Torres A, et al. Anal. Bioanal. Chem 405(7), 2397-404, (2013)

Loading...


PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Luo H, Yang Y, Duan J, et al. Cell Death Dis. 4, e481, (2013)

Loading...


Hypoxia promotes progesterone synthesis during luteinization in bovine granulosa cells. Fadhillah, Yoshioka S, Nishimura R, et al. J. Reprod. Dev. 60(3), 194-201, (2014)

Loading...


Bioavailability, toxicity and biotransformation of selenium in midge (Chironomus dilutus) larvae exposed via water or diet to elemental selenium particles, selenite, or selenized algae. Gallego-Gallegos M, Doig LE, Tse JJ, et al. Environ. Sci. Technol. 47(1), 584-92, (2013)

Loading...


Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo. Shi K, Jiang Q, Li Z, et al. J. Hematol. Oncol. 6, 7, (2013)

Loading...


A balanced diet is necessary for proper entrainment signals of the mouse liver clock. Akiko Hirao et al PLoS ONE 4, e6909, (2009)

Loading...


Selenoprotein P inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury. Eckers JC, Kalen AL, Xiao W, et al. Int. J. Radiat. Oncol. Biol. Phys. 87(3), 619-25, (2013)

Loading...


Regulation of selenoprotein P concentration and expression by different sources of selenium in broiler breeders and their offspring. Yuan D, Zheng L, Guo XY, et al. Poult. Sci. 92(9), 2375-80, (2013)

Loading...


Selenium (sodium selenite) causes cytotoxicity and apoptotic mediated cell death in PLHC-1 fish cell line through DNA and mitochondrial membrane potential damage. Selvaraj V, Tomblin J, Yeager Armistead M, et al. Ecotoxicol. Environ. Saf. 87, 80-8, (2013)

Loading...


Selenium for the prevention of cutaneous melanoma. Cassidy PB, Fain HD, Cassidy JP, et al. Nutrients 5(3), 725-49, (2013)

Loading...


Dietary selenium supplementation modifies breast tumor growth and metastasis. Chen YC, Prabhu KS, Das A, et al. Int. J. Cancer 133(9), 2054-64, (2013)

Loading...


Selenite adsorption using leached residues generated by reduction roasting-ammonia leaching of manganese nodules. Randhawa NS, Das NN, and Jana RK J. Hazard. Mater. 241-242, 486-92, (2012)

Loading...


Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis. Shukla A Am. J. Pathol. 175(5), 2197-206, (2009)

Loading...


Reduced swim performance and aerobic capacity in adult zebrafish exposed to waterborne selenite. Massé AJ, Thomas JK, and Janz DM Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 157(3), 266-71, (2013)

Loading...


Galectin-3 contributes to luteolysis by binding to Beta 1 integrin in the bovine corpus luteum. Hashiba K, Sano M, Nio-Kobayashi J, et al. Biol. Reprod. 91(1), 2, (2014)

Loading...


High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Sun K, Wu S, Wang Y, et al. Food Chem. Toxicol. 52, 36-41, (2013)

Loading...


The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Eder-Colli L Brain Res. Bull. 80(4-5), 296-301, (2009)

Loading...


Plasma and breast-milk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementation: results of the Breastfeeding, Antiretrovirals, and Nutrition study. Flax VL, Bentley ME, Combs GF, et al. Am. J. Clin. Nutr. 99(4), 950-6, (2014)

Loading...


Effect of sulfide, selenite and mercuric mercury on the growth and methylation capacity of the sulfate reducing bacterium Desulfovibrio desulfuricans. Truong HY, Chen YW, and Belzile N Sci. Total Environ. 449, 373-84, (2013)

Loading...


Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus. Luebke JL, Arnold RJ, and Giedroc DP Metallomics 5(4), 335-42, (2013)

Loading...


Intra-operatively obtained human tissue: protocols and techniques for the study of neural stem cells. Chaichana, KL., et al. J. Neurosci. Methods 180(1), 116-125, (2009)

Loading...


Selenium bioaccessibility and bioavailability in Se-enriched food supplements. Thiry C, Schneider YJ, Pussemier L, et al. Biol. Trace Elem. Res. 152(1), 152-60, (2013)

Loading...


Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines. Rusolo F, Pucci B, Colonna G, et al. Molecules 18(3), 2549-62, (2013)

Loading...


Porcine serum can be biofortified with selenium to inhibit proliferation of three types of human cancer cells. Sun LH, Li JG, Zhao H, et al. J. Nutr. 143(7), 1115-22, (2013)

Loading...


Cancer stem-like cells enriched in panc-1 spheres possess increased migration ability and resistance to gemcitabine. Yin, T Int. J. Mol. Sci. 12(3), 1595-604, (2011)

Loading...


Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. Mendelev N, Mehta SL, Idris H, et al. PLoS ONE 7(10), e47910, (2012)

Loading...


Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. Liu J, Liu Y, Wang H, et al. Sci. Rep. 3, 1185, (2013)

Loading...


Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy. Somnath Singha Roy et al Bioorg. Med. Chem. Lett. 20, 6951-5, (2010)

Loading...


Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. Abdulah R BMC Cancer 9, 414, (2009)

Loading...


The effect of apricots on the experimental cataract model formed by sodium selenite. Doganay S, Duz C, Firat PG, et al. Food Chem. Toxicol. 55, 371-7, (2013)

Loading...


Sodium selenite improves folliculogenesis in radiation-induced ovarian failure: a mechanistic approach. Said RS, Nada AS, and El-Demerdash E PLoS ONE 7(12), e50928, (2012)

Loading...


Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection. Palsamy P, Bidasee KR, and Shinohara T Biochim. Biophys. Acta 1842(9), 1794-805, (2014)

Loading...


Co-application of selenite and phosphate reduces arsenite uptake in hydroponically grown rice seedlings: toxicity and defence mechanism. Kumar N, Mallick S, Yadava RN, et al. Ecotoxicol. Environ. Saf. 91, 171-9, (2013)

Loading...


Effect of blood-retinal barrier development on formation of selenite nuclear cataract in rat. Chen H, Tian W, and Huang K Toxicol. Lett. 216(2-3), 181-8, (2013)

Loading...


Hematological, biochemical and enzymological responses in an Indian major carp Labeo rohita induced by sublethal concentration of waterborne selenite exposure. Ramesh M, Sankaran M, Veera-Gowtham V, et al. Chem. Biol. Interact. 207, 67-73, (2014)

Loading...


Effects of dietary selenium supplementation on parasitemia, anemia and serum proteins of Trypanosoma brucei brucei infected rats. Eze JI, Okeke MC, Ngene AA, et al. Exp. Parasitol. 135(2), 331-6, (2013)

Loading...


Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models. Velpandian T, Gupta P, Ravi AK, et al. BMC Complement Altern. Med. 13, 1, (2013)

Loading...


Selenium species and their distribution in freshwater fish from Argentina. Kristan U, Arribére MA, and Stibilj V Biol. Trace Elem. Res. 151(2), 240-6, (2013)

Loading...


Selenium supplementation shows protective effects against patulin-induced brain damage in mice via increases in GSH-related enzyme activity and expression. Song E, Su C, Fu J, et al. Life Sci. 109(1), 37-43, (2014)

Loading...


Effects of selenoprotein P on the contraction and relaxation of the airway smooth muscle. Ogawa SK, Shin MC, Hirashima M, et al. Gen. Physiol. Biophys. 32(1), 47-54, (2013)

Loading...


Influence of trace elements on stabilization of aqueous solutions of ascorbic acid. Dolińska B, Ostróżka-Cieślik A, Caban A, et al. Biol. Trace Elem. Res. 150(1-3), 509-12, (2012)

Loading...


Role of selenium in protection of liver cirrhosis. Fatima SN and Mahboob T Pak. J. Pharm. Sci. 26(6), 1097-102, (2013)

Loading...


Merck 14,8673

Aldrich MSDS 1, 1614:B / Corp MSDS 1 (2), 3153:D / RegBook 1 (3), 3509:H / Sax 6, 2451 / Sigma FT-IR 1 (2), 1047:B

Related Products

related product

Product #

Description

Add to Cart

I1884 Insulin-transferrin-sodium selenite media supplement, γ-irradiated, lyophilized powder, BioXtra, suitable for cell culture
S5666 SPITE Medium Supplement (100×), liquid, sterile-filtered, BioReagent, suitable for cell culture

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?