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S5261 Sigma

Sodium selenite

BioReagent, suitable for cell culture, ≥98%

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Properties

Related Categories Antioxidant, Cell Biology, Chemical Synthesis, Functional Foods, Inorganic Salts,
product line   BioReagent
assay   ≥98%
form   powder
mp   >350 °C(lit.)
suitability   suitable for cell culture

Description

Packaging

10, 25, 100 g in glass bottle

Application

Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.

This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
Contact with acids liberates toxic gas.
RIDADR 
UN2630 - class 6.1 - PG 1 - EHS - Selenites, HI: all (not BR)
WGK Germany 
2
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers
15

References

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