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S5269 Sigma

Serum amyloid P component human

buffered aqueous solution

Synonym: Amyloid P component from serum

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Proteins of Inflammation More...
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... APCS(325)

Description

Biochem/physiol Actions

Serum amyloid P component (SAP) is named for its universal presence in amyloid deposits (senile plaque and neurofibrillary tangles) in Alzheimer patients although it is exclusively synthesized in the periphery. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A beta deposition since no endogenous SAP immunoreactivity was detectable in transgenic mouse overexpressing beta-protein precursor. SAP belongs to the pentraxins family of oligomeric serum proteins which is highly conserved through evolution. Its presence has been found in Limulus polyphemus haemolymph. A recent report demonstrated that, in the presence of calcium, SAP can bind to free DNA and chromatin released through apoptosis or necrosis, displacing histone H1 and causing its solubilization and degradation. SAP knock out mice developed antinuclear autoimmunity and glomerulonephritis. However, the protective role of SAP in human SLE is still controversial. In addition, SAP neutralizes LPS and is potentially useful in defense against serious gram-negative sepsis in humans.

Physical form

Solution in 0.01 M Tris, 0.14 M NaCl at pH 8.0 containing 0.01 M EDTA and 0.1% (w/v) NaN3

Price and Availability


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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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