Synonym: Sodium hydrogen carbonate
|Related Categories||Apoptosis and Cell Cycle, Biological Buffers, Buffers, Cell Biology, Cell Culture,|
|grade||for molecular biology|
|pH range||6.8 - 7.4|
|pKa (25 °C)||(1) 6.37, (2) 10.25 (carbonic acid)|
|suitability||suitable for cell culture|
|suitable for insect cell culture|
Sodium bicarbonate is broadly used as a physiological buffer in cell culture applications. The pKa for bicarbonate <-> carbonic acid reaction is 6.4 The pKa for bicarbonate <-> carbonate reaction is 10.3. Sodum bicarbonate has two pKas, 6.4 and 10.3. It is broadly used as an physiological buffer in in vitro applications.
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Inhibition studies with anions and small molecules of two novel ?-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. Daniela Vullo et al Bioorg. Med. Chem. Lett. 21, 3591-5, (2011)
Purification and inhibition studies with anions and sulfonamides of an ?-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii. Alessandra Cincinelli et al Bioorg. Med. Chem. 19, 1847-51, (2011)
Inhibition of the ?-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? Peter Burghout et al Bioorg. Med. Chem. 19, 243-8, (2011)
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