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S6201 Sigma

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

Synonym: Antibiotic 61477, Coxxistac

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Properties

Related Categories Antibacterial, Antibiotic Ready Made Solutions, Antibiotics, Antibiotics A to Z, Antibiotics N-S,
biological source   from Streptomyces albus
InChI Key   KQXDHUJYNAXLNZ-XQSDOZFQSA-N
assay   ≥98% (HPLC)
concentration   2 mg/ml
solubility   DMSO: soluble
  H2O: insoluble
  alcohols: soluble
  carbon tetrachloride: soluble
  chloroform: soluble
  ethers and esters: soluble
  hexane: soluble
Mode of action   cell membrane | interferes
shipped in   dry ice
storage temp.   −20°C

Description

Physical form

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

Application

Salinomycin was used to induce apoptosis in human CD4+ T-cell leukemia cells4 and gastric cancer cells.5

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

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Safety Information

RIDADR 
NA 1993 / PGIII
WGK Germany 
2
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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