|Related Categories||1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics,|
|suitability||suitable for 1694 per US EPA|
An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections1. It is used in disposition and depletion kinetic studies2,3. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine4.
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From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System - Thyroid Gland
Keywords: Cancer, Carcinogens, Respiratory
From our library of Related Content, Sigma-Aldrich presents Carcinogen Selector - Endocrine System
Keywords: Cancer, Carcinogens, Respiratory
Development of an HPLC method to analyze four veterinary antibiotics in soils and aqueous media and validation through fate studies. Srinivasan P, Sarmah AK, Manley-Harris M, et al. J. Environ. Sci. Health. A. Tox. Hazard. Subst. Environ. Eng. 47(13), 2120-32, (2012)
Sorption behavior of sulfamethazine on unamended and manure-amended soils and short-term impact on soil microbial community. Pinna MV, Castaldi P, Deiana P, et al. Ecotoxicol. Environ. Saf. 84, 234-42, (2012)
A simple, semiselective medium for anaerobic isolation of anginosus group streptococci from patients with chronic lung disease. Waite RD, Wareham DW, Gardiner S, et al. J. Clin. Microbiol. 50(4), 1430-2, (2012)
Acetylator status and N-acetyltransferase 2 gene polymorphisms; phenotype-genotype correlation with the sulfamethazine test. Taja-Chayeb L, González-Fierro A, Miguez-Muñoz C, et al. Pharmacogenet. Genomics 21(12), 894-901, (2011)
Bovine respiratory disease: efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae. Rérat M, Albini S, Jaquier V, et al. Prev. Vet. Med. 103(4), 265-73, (2012)
Effects of sulfamethazine on induction of precocious puberty in Japanese quails (Coturnix japonica) assessed through monitoring the hormonal changes and gonadal development. Sedqyar M, Kandiel MM, Weng Q, et al. J. Reprod. Dev. 58(5), 563-8, (2012)
Continuous degradation of a mixture of sulfonamides by Trametes versicolor and identification of metabolites from sulfapyridine and sulfathiazole. Rodríguez-Rodríguez CE, García-Galán MA, Blánquez P, et al. J. Hazard. Mater. 213-214, 347-54, (2012)
Biodegradation studies of N4-acetylsulfapyridine and N4-acetylsulfamethazine in environmental water by applying mass spectrometry techniques. García-Galán MJ, Frömel T, Müller J, et al. Anal. Bioanal. Chem 402(9), 2885-96, (2012)
Producing a sulfamethazine quality control material under the framework of ISO/CD Guide 80. Cunha AL, Silva PF, Souza EA, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(4), 571-6, (2012)
Kinetic studies and characterization of photolytic products of sulfamethazine, sulfapyridine and their acetylated metabolites in water under simulated solar irradiation. García-Galán MJ, Díaz-Cruz MS, and Barceló D Water Res. 46(3), 711-22, (2012)
Biodegradation of sulfamethazine by Trametes versicolor: Removal from sewage sludge and identification of intermediate products by UPLC-QqTOF-MS. García-Galán MJ, Rodríguez-Rodríguez CE, Vicent T, et al. Sci. Total Environ. 409(24), 5505-12, (2011)
Proton-transfer compounds with 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (sulfamethazine): the structures and hydrogen bonding in the salts with 5-nitrosalicylic acid and picric acid. Smith G and Wermuth UD Acta Crystallogr. C, Cryst. Struct. Commun. 69(Pt 5), 538-43, (2013)
Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling. Curtin V, Amharar Y, Hu Y, et al. Mol. Pharm. 10(1), 386-96, (2013)
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