Sulfamethazine ≥99% | Sigma-Aldrich

Properties

Related Categories	1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Drug and Xenobiotic Metabolism, EPA, Inhibits an Enzyme, Interferes with DNA Synthesis, L - Z, Mechanism of Action, Method and Regulation Specific, Multi-Drug Resistance and Drug Metabolism, Neats, S, Spectrum of Activity, Substrates, Inducers, Inhibitors, Sulfonamides More...
assay	≥99%
suitability	suitable for 1694 per US EPA
storage temp.	2-8°C

Description

Biochem/physiol Actions

An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid¹. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Application

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections¹. It is used in disposition and depletion kinetic studies^2,³. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine⁴.