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S6936 Sigma

Anti-Sodium Channel, Pan antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-SP19

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Sodium Channels,
species reactivity   rat
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  immunoprecipitation: suitable
  western blot (chemiluminescent): 1:200-1:600
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   rat ... Scn1a(81574)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 1491-1508 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP19) (with additional C-terminal cysteine). The epitope corresponds to the sequence in the intracellular loop between the III and IV domains of the VGSC α subunit.This epitope is identical in vertebrates, and highly homologous in mollusks and insects.

General description

Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Application

Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

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Safety Information

Symbol  GHS06  GHS06
Signal word  Danger
Hazard statements  H301 + H311-H412
Precautionary statements  P273-P280-P301 + P310 + P330-P302 + P352 + P312
Supplemental Hazard Statements  Contact with acids liberates very toxic gas.
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Protocols & Articles

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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