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S7004 Sigma

Sphingomyelin

from bovine brain, ≥97.0%, powder

Synonym: N-Acyl-4-sphingenyl-1-O-phosphorylcholine, N-Acyl-D-sphingosine-1-phosphocholine

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Description

Other Notes

Contains primarily stearic, nevonic, and lignoceric acids.

Application

Sphingomyelin was used as exogenous treatment to study the effect on ATP depletion and Fe-mediated cell injury in human proximal tubular cell line, HK-2 cells.3 It was used to study the effect on Akt phosphorylation in obese mice.4

Biochem/physiol Actions

Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling.1 Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.2

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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