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S7004 Sigma

Sphingomyelin

from bovine brain, ≥97.0%, powder

Synonym: N-Acyl-4-sphingenyl-1-O-phosphorylcholine, N-Acyl-D-sphingosine-1-phosphocholine

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Description

Other Notes

Contains primarily stearic, nevonic, and lignoceric acids.

Application

Sphingomyelin was used as exogenous treatment to study the effect on ATP depletion and Fe-mediated cell injury in human proximal tubular cell line, HK-2 cells.3 It was used to study the effect on Akt phosphorylation in obese mice.4

Biochem/physiol Actions

Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling.1 Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.2

Price and Availability


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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

LC/MS Analysis of Phospholipids in Milk on Ascentis® Express HILIC after SPE using Supelclean™ Si, Shotgun HPLC Analysis

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Phospholipids in Milk on Ascentis® Express HILIC after SPE using Supelclean™ Si, Shotgun HPLC Analysis
Keywords: Chromatography, High performance liquid chromatography, Solid phase extractions

Peer-Reviewed Papers
15

References

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