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S7389 Sigma

SB-269970 hydrochloride

powder, ≥98% (HPLC)

Synonym: (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride, SB 269970A

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Properties

Related Categories Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   XQCJOYZLWFNDIO-PKLMIRHRSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
solubility   H2O: soluble10 mg/mL, clear (warmed to 60 °C)
storage temp.   2-8°C
Gene Information   human ... HTR7(3363)

Description

Biochem/physiol Actions

Selective 5-HT7 serotonin receptor antagonist.

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT7 receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.4 SB-269970 desensitizes and decreases the excitatory effects of 5-HT7 receptors in rat hippocampus.5

Legal Information

Sold with the permission of GlaxoSmithKline Pharmaceuticals

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Application

SB-269970 was used to study the role of 5-HT7 receptors in serotonin-induced hypothermia in rodents.6

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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L3169 LP 12 hydrochloride hydrate, ≥98% (HPLC), solid

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