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S7936 Sigma

SB 205384

solid

Synonym: 4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   JDTZAGLGBRRCJT-UHFFFAOYSA-N
form   solid
color   off-white
solubility   DMSO: soluble18 mg/mL
  H2O: insoluble

Description

Biochem/physiol Actions

GABAA receptor modulator selective for the α3β2γ2 subunit combination.

SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABAA receptor.3 It affects the extrasynaptic GABAA receptors in rat cortical neurons4 and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.5

Legal Information

Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Application

SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.6

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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Neuroscience Grant Programm
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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