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S8071 Sigma

Salvinorin A

≥98% (HPLC), powder

Synonym: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   OBSYBRPAKCASQB-AGQYDFLVSA-N
assay   ≥98% (HPLC)
form   powder
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
storage condition   protect from light
color   white
solubility   DMSO: ≥10 mg/mL
  ethanol: ~3 mg/mL
storage temp.   −20°C
Gene Information   human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprk1(29335)

Description

Application

Salvinorin A was administered to rats to study effects on lactic acid-stimulated stretching.1

Biochem/physiol Actions

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
QL6127142

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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