Salbutamol

Papers

Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Xiaojie Yao et al Nat. Chem. Biol. 2, 417-22, (2006)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol. Christopher Kern et al J. Med. Chem. 52, 1773-7, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist. Marvin A Soriano-Ursúa et al Eur. J. Med. Chem. 44, 2840-6, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist. François Baur et al J. Med. Chem. 53, 3675-84, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Design driven HtL: The discovery and synthesis of new high efficacy ??-agonists. Michael J Stocks et al Bioorg. Med. Chem. Lett. 21, 4027-31, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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A multivalent approach to the discovery of long-acting ?(2)-adrenoceptor agonists for the treatment of asthma and COPD. John R Jacobsen et al Bioorg. Med. Chem. Lett. 22, 1213-8, (2012)

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Albuterol-induced downregulation of Gsalpha accounts for pulmonary β2-adrenoceptor desensitization in vivo. Finney, P.A., et al. J. Clin. Invest. 106, 125-135, (2000)

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The β2-agonist salbutamol inhibits bronchoconstriction and leukotriene D₄ synthesis after dry gas hyperpnea in the guinea-pig. Yang, X.X., et al. Pulm. Pharmacol. 12, 325-329, (1999)

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The asthma-like pharmacology and toxicology of (S)-isomers of β agonists. Handley, D., J. Allergy Clin. Immunol. 104, S69-S76, (1999)

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Merck 14,216