|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,|
|color||white to off-white|
|solubility||DMSO: ≥20 mg/mL|
|Gene Information||human ... CYP1A2(1544), CYP2C19(1557), CYP2C9(1559), CYP2D6(1565), CYP3A4(1576), IL1B(3553), MAPK14(1432), MAPK8IP2(23542), RAF1(5894), TNF(7124)|
SB 203580 is a pyridinyl imidazole that suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein (HSP) 27 in response to IL-1, cellular stresses and bacterial endotoxin in vivo. It does not inhibit JNK or p42 MAP kinase and therefore, is useful for studying the physiological roles and targets of p38 MAPK and MAPKAP kinase-2. It has been shown to induce the activation of the serine/threonine kinase Raf-1 and has been reported to inhibit cytokine production.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P280-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-41|
|Safety Statements (Europe)||26-39|
A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock. Perales M, Mas P Plant Cell, 2111-23, (2005)
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. Chen LY, Woszczek G, Nagineni S, Logun C, Shelhamer JH Am. J. Physiol. Lung Cell. Mol. Physiol., L326-35, (2008)
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