SB 203580
solid, ≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
4-
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CAS Number 152121-47-6
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Empirical Formula (Hill Notation) C21H16FN3OS
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Molecular Weight 377.43
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MDL number MFCD00922198
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PubChem Substance ID 24899788
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Popular Documents: Product Information Sheet (PDF)
Properties
| Related Categories | Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | −20°C |
| Gene Information | human ... CYP1A2(1544), CYP2C19(1557), CYP2C9(1559), CYP2D6(1565), CYP3A4(1576), IL1B(3553), MAPK14(1432), MAPK8IP2(23542), RAF1(5894), TNF(7124) |
Description
Biochem/physiol Actions
SB 203580 is a pyridinyl imidazole that suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein (HSP) 27 in response to IL-1, cellular stresses and bacterial endotoxin in vivo. It does not inhibit JNK or p42 MAP kinase and therefore, is useful for studying the physiological roles and targets of p38 MAPK and MAPKAP kinase-2. It has been shown to induce the activation of the serine/threonine kinase Raf-1 and has been reported to inhibit cytokine production.
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