Sinefungin
95% (HPLC), powder
DOWNLOAD MSDS (PDF)Synonym: 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP
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CAS Number 58944-73-3
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Empirical Formula (Hill Notation) C15H23N7O5
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Molecular Weight 381.39
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PubChem Substance ID 24899800
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Popular Documents: Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Bioactive Small Molecules, |
| assay | 95% (HPLC) |
| form | powder |
| color | white to yellow |
| solubility | H2O: soluble |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.
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