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S8689 Sigma

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

Synonym: SuperFas Ligand

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptor Ligands, Death Receptors, Ligands and Antibodies More...
recombinant   expressed in HEK 293 cells
form   lyophilized powder
mol wt   mol wt 32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
  mol wt 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
storage temp.   −20°C
Gene Information   human ... FASLG(356)

Description

Application

ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFasL recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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