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S8809 Sigma

Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse

~1 mg/mL, clone K58/35, purified immunoglobulin

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Ion Channels, Antibodies to Sodium Channels,
species reactivity   mammals
application(s)   immunohistochemistry (frozen sections): suitable
  indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
  western blot: 1 μg/mL using crude brain membrane prep (rat)
clone   K58/35, monoclonal
concentration   ~1 mg/mL
antibody form   purified immunoglobulin
isotype   IgG1
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN8A(6334), SCN9A(6335)
mouse ... Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a(20271), Scn8a(20273), Scn9a(20274)
rat ... Scn10a(29571), Scn11a(29701), Scn1a(81574), Scn3a(497770), Scn4a(25722), Scn5a(25665), Scn8a(29710), Scn9a(78956)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide CTEEQKKYYNAMKKLGSKK from the intracellular III-IV loop of Na+ channels

Physical form

Solution in 10 mM Tris, pH 7.5, containing 0.1 m NaCl, 30% glycerol, and 15 mM sodium azide.

Specificity

The sequence recognized by this clone is identical in all known vertebrate Na+ channels. In cultured hippocampal neurons, the antibody specifically stains the axon initial segment. In sciatic and optic nerves, it stains the nodes of Ranvier.

Legal Information

Sold under exclusive license from SUNY Stony Brook.

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