EMAIL THIS PAGE TO A FRIEND
S9066 Sigma

SKF-89976A

>98% (HPLC), solid

Synonym: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride

  • CAS Number 85375-15-1

  • Empirical Formula (Hill Notation) C22H25NO2 · HCl

  • Molecular Weight 371.90

  •  MDL number MFCD01321071

  •  PubChem Substance ID 24278796

Purchase

Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   SNGGBKYQZVAQKA-UHFFFAOYSA-N
assay   >98% (HPLC)
form   solid
color   white
solubility   DMSO: soluble20 mg/mL
  H2O: insoluble
originator   GlaxoSmithKline
storage temp.   2-8°C
Gene Information   human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Slc6a1(79212), Slc6a12(50676)

Description

Biochem/physiol Actions

GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.

SKF-89976A contains a cyclic amino acid with lipophilic moiety that enables the compound to cross the blood-brain barrier.1,2 It decreases the excitotoxic swelling of chick retina cells by blocking the glutamate-induced GABA release.3

Packaging

10, 50 mg in glass bottle

Application

SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.4,5

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability


Better Together

Discover your Target

Making Headway
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?