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S9186 Sigma

SIB 1757

≥99% (HPLC), crystalline

Synonym: 6-Methyl-2-(phenylazo)-3-pyridinol

  • Empirical Formula (Hill Notation) C12H11N3O

  • Molecular Weight 213.24

  •  MDL number MFCD00506102

  •  PubChem Substance ID 24278717

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Description

Application

SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem/physiol Actions

SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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GHS07  GHS07
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Warning
Hazard statements 
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Protocols & Articles
Peer-Reviewed Papers
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