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S9311 Sigma

SIB 1893

>99%, solid

Synonym: [E]-2-Methyl-6-[2-phenylethenyl]pyridine

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Description

Biochem/physiol Actions

Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist.

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 It also acts as a positive allosteric modulator of hmGluR4.2

Packaging

10 mg in ampule

Application

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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