Sphingomyelinase from Bacillus cereus
buffered aqueous glycerol solution, ≥100 units/mg protein (Lowry)
DOWNLOAD MSDS (PDF)Synonym: Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase
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CAS Number 9031-54-3
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MDL number MFCD00132362
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Popular Documents: Datasheet (PDF) | Specification Sheet (PDF)
| Properties
| Related Categories | 3.1.x.x Acting on esters, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, |
| form | buffered aqueous glycerol solution |
| foreign activity | Phospholipase C ≤1% |
| storage temp. | 2-8°C |
| Gene Information | Bacillus cereus ATCC 10987 ... spH(2751530) |
Description
Unit Definition
One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
Physical form
Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.
Application
Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. 1 Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems. 2
Biochem/physiol Actions
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
Price and Availability
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