Synonym: Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase
|Related Categories||3.1.x.x Acting on esters, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates,|
|form||buffered aqueous glycerol solution|
|foreign activity||Phospholipase C ≤1%|
|Gene Information||Bacillus cereus ATCC 10987 ... spH(2751530)|
One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5.
Sphingomyelinase has been used in a study to assess the interaction of actin with the HIV-1 accessory protein Nef. 1 Sphingomyelinase has also been used in a study to investigate X-ray scattering as a quality-control tool for liposomal drug-delivery systems. 2
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
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from chicken egg yolk, ≥95%
lyophilized powder, ≥100 units/mg protein
buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)
1 mg/mL in chloroform/methanol (2:1)
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