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S9564 Sigma

Amyloid Precursor Protein α, Secreted human

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

Synonym: sAPPα

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Properties

Related Categories Alzheimer′s Disease, Amyloid Precursor Proteins and Fragments, Cell Biology, Cell Signaling and Neuroscience, Neurobiology,
recombinant   expressed in E. coli (N-terminal histidine tagged)
assay   >90% (SDS-PAGE)
form   buffered aqueous solution
mol wt   mol wt ~100 kDa by SDS-PAGE
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... APP(351)

Description

Preparation Note

Expressed as a soluble protein and purified under non-denaturing conditions.

Physical form

Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.

Biochem/physiol Actions

α−secretase-cleaved soluble amyloid precursor protein has been shown to have neuroprotective properties. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP.

Price and Availability


Amplified Detection

Making Headway

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions. Hallmark pathohistological findings of AD include widespread ...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 4–8
Keywords: Alzheimer Disease, Gene expression, Genetic, Genetics, Inflammation, Metabolism, Phosphorylations

Peer-Reviewed Papers
15

References

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