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S9652 Sigma

Safrole

≥97%

Synonym: 4-Allyl-1,2-methylenedioxybenzene, 5-Allyl-1,3-benzodioxole

  • CAS Number 94-59-7

  • Empirical Formula (Hill Notation) C10H10O2

  • Molecular Weight 162.19

  •  Beilstein Registry Number 136380

  •  EC Number 202-345-4

  •  MDL number MFCD00005841

  •  PubChem Substance ID 24899851

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Cancer Research, Carcinogens, Cell Biology, Ephedra sinica, Nutrition Research,
vapor pressure   1 mmHg ( 63.8 °C)
InChI Key   ZMQAAUBTXCXRIC-UHFFFAOYSA-N
assay   ≥97%
color   yellow
refractive index   n20/D 1.537(lit.)
bp   232-234 °C(lit.)
mp   11.2 °C(lit.)
density   1.095 g/mL at 25 °C(lit.)

Description

Biochem/physiol Actions

Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.

Other Notes

Principal constituent of sassafras oil

Packaging

50, 500 mL in glass bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
3
RTECS 
CY2800000
Flash Point(F) 
212 °F
Flash Point(C) 
100 °C
Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification

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Peer-Reviewed Papers
15

References

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