|Related Categories||Angiogenesis, Angiogenic Factors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research,|
|Gene Information||human ... S1PR1(1901), S1PR2(9294), S1PR3(1903), S1PR4(8698), S1PR5(53637)|
A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
Although historically considered as intermediates in the biosynthesis of glycerophospholipids and the degradation of sphingolipids, the lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1...
Keywords: Atomic absorption spectroscopy, Cancer, Chemical biology, Degradations, Gene expression, Genetic, Genetics, Ligands, Phosphorylations, Transduction
Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Okamoto H, Takuwa N, Yokomizo T, et al. Mol. Cell. Biol. 20(24), 9247-61, (2000)
S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. Szczepaniak WS, Pitt BR, and McVerry BJ Am. J. Physiol. Lung Cell. Mol. Physiol. 299(1), L137-45, (2010)
A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Cinq-Frais C, Coatrieux C, Grazide MH, et al. Biochim. Biophys. Acta 1831(8), 1344-56, (2013)
Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Kikuta J, Kawamura S, Okiji F, et al. Proc. Natl. Acad. Sci. U. S. A. 110(17), 7009-13, (2013)
Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. Natarajan V, Dudek SM, Jacobson JR, et al. Am. J. Respir. Cell. Mol. Biol. 49(1), 6-17, (2013)
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. Sobel K, Menyhart K, Killer N, et al. J. Biol. Chem. 288(21), 14839-51, (2013)
FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. Vessey DA, Li L, Imhof I, et al. Med. Sci. Monit. Basic Res. 19, 126-32, (2013)
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