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  • S9685 - Structure-Function Analysis of G Protein-Coupled Receptors

S9685 Sigma

Structure-Function Analysis of G Protein-Coupled Receptors

  •  ISBN-10 0-471-25228-X

  •  ISBN-13 978-0-471-25228-3



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publication info   J. Wess, ed., Wiley-Liss, 1999, 412 pp., hard cover
mfr. no.   Wiley


General description

G Protein Coupled Receptors (GPCR) often play key roles in a large number of physiological and pathophysiological conditions. Theses receptors are the targets of a large number of therapeutic drugs. Detailed knowledge about the molecular structure of GPCRs should pave the way for more efficient drugs. This lab-friendly guide provides a concise, up-to-date presentation of methods which have been used successfully in studying structure and function of GPCRs.

Table of Contents

Partial TOC
Overview of Mutagenesis Techniques .  
The Substituted-Cysteine Accessibility Method  
Metal-Ions as Atomic Scale Probes of G Protein-Coupled Receptor Structure  
Genetic Approaches for Studying the Structure and Function of G Protein-Coupled Receptors in Yeast
Electron-Crystallographic Analysis of Two-Dimensional Rhodopsin Crystals  
Site-Directed Spin-Labeling (SDSL)
Studies of the G Protein-Coupled Receptor Rhodopsin
Lead Discovery and Development for G Protein-Coupled Receptors  

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