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S9944 Sigma

Sibutramine hydrochloride monohydrate

≥98% (HPLC), solid

Synonym: 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil

  • CAS Number 125494-59-9

  • Empirical Formula (Hill Notation) C17H26ClN · HCl · H2O

  • Molecular Weight 334.32

  •  MDL number MFCD04039806

  •  PubChem Substance ID 329824638

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Description

Application

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.1

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Obesity, Pharmaceutical

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Obesity, Pharmaceutical

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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