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  • S9947 - Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat

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S9947 Sigma

Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat

clone 55626, purified immunoglobulin, lyophilized powder

Synonym: Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh

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Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins, Bioactives, Markers, and Receptors for Stem Cell Biology, Antibodies for Cell Biology, Antibodies to Angiogenic Factors,
species reactivity   mouse
application(s)   western blot: 1-2 μg/mL
clone   55626, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2a
storage temp.   −20°C
Gene Information   mouse ... Shh(20423)
biological source   rat
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog C-terminal peptide (aa 199-437).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb, and axon guidance factors during the development of brain and nervous system.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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